Host genetic factors determining COVID-19 susceptibility and severity

Host genetic factors determining COVID-19 susceptibility and severity

Blog Article

The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) poses an unprecedented challenge to humanity.SARS-CoV-2 infections range from asymptomatic to severe courses of COVID-19 with acute respiratory distress syndrome (ARDS), multiorgan involvement and death.Risk factors for disease click here severity include older age, male sex, increased BMI and pre-existing comorbidities.Ethnicity is also relevant to COVID-19 susceptibility and severity.

Host genetic predisposition to COVID-19 is now increasingly recognized and whole genome and candidate gene association studies regarding COVID-19 susceptibility have been performed.Several common and rare variants in genes related to inflammation or immune responses have been iphone 13 price ohio identified.We summarize research on COVID-19 host genetics and compile genetic variants associated with susceptibility to COVID-19 and disease severity.We discuss candidate genes that should be investigated further to understand such associations and provide insights relevant to pathogenesis, risk classification, therapy response, precision medicine, and drug repurposing.